Gene Model 129 (Gm129) Encodes a Novel Transcriptional Repressor That Modulates Circadian Gene Expression

Jan 4, 2014The Journal of biological chemistry

Gene model 129 produces a new protein that controls daily gene activity

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Abstract

Gm129 is identified as a novel regulator in the mammalian circadian feedback loop.

  • The CLOCK·BMAL1 complex strongly binds to the promoter region of Gm129.
  • Both mRNA and protein levels of GM129 show high amplitude circadian fluctuations in mouse liver.
  • GM129 encodes a protein that directly interacts with BMAL1 and represses CLOCK·BMAL1 activity.
  • GM129 functions similarly to Cryptochrome 1 (CRY1) by binding to the CLOCK·BMAL1 complex on DNA and acting as a repressor.
  • Gm129(-/-) or Cry1(-/-) Gm129(-/-) mice maintain a robust circadian rhythm, but exhibit a significant phase delay in Nr1d1 and Dbp mRNA peaks.

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