Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity

Acute activation of PPG neurons in the brainstem reduces basal glucose production and enhances glucose tolerance.

• Activation of PPG neurons is associated with improved glucose tolerance following an intraperitoneal glucose tolerance test.
• Enhanced insulin sensitivity was observed, indicated by an increased rate of glucose infusion during metabolic assessments.
• Basal endogenous glucose production was downregulated after PPG neuron activation.
• Insulin-stimulated glucose disposal did not show significant changes.
• These findings suggest that PPG neurons may play a crucial role in regulating energy balance and glucose homeostasis.

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