INTRODUCTION: The morphologic and physiologic changes with use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) are known to the dermatologic surgery community. More specifically, many patients note changes in periorificial appearance relating to inadvertent cosmetic and oral health concerns that span not only dermatology but also dentistry. This article explores the overlap between the dentistry and dermatology fields in managing effects of this class of medications.
METHODS: The available peer-reviewed literature evaluating perioral changes and impacts of the GLP1RAs was evaluated in the PubMed database.
RESULTS: The findings from the review of the peer-reviewed literature were limited. These findings were combined with clinical experience and reports from related topics to identify culprits for the clinical findings including but not limited to skin changes, volume loss, xerostomia, and periodontal changes. In addition, opportunities for collaborative efforts for patient care were explored.
DISCUSSION/CONCLUSION: The benefit of a collaborative effort of dermatologic surgeons and dentists is demonstrated. This multidisciplinary collaboration can yield comprehensive solutions to some of the less desirable adverse effects of GLP1RAs.
