Glucagon-like peptide-1 receptor drugs as add-on treatment for hard-to-treat high blood fat after repeated pancreas inflammation

Peak triglycerides reached 2329 mg/dL despite maximal therapy with standard medications.

• A 39-year-old man experienced multiple episodes of pancreatitis linked to high triglyceride levels.
• Comorbidities included poorly managed diabetes, recurrent low blood sugar, and moderate liver fibrosis.
• Initiation of semaglutide led to triglyceride normalization at 213 mg/dL, along with weight loss and better blood sugar control.
• Hypoglycemia resolved, liver health improved, and insulin was no longer needed without any pancreatitis recurrence.
• This case suggests that glucagon-like peptide-1 receptor agonists may be a viable option for patients with high triglycerides and a history of pancreatitis.

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