Understanding the Effects of Gut Microbiota Dysbiosis on Nonalcoholic Fatty Liver Disease and the Possible Probiotics Role: Recent Updates

Mar 26, 2021International journal of biological sciences

How Imbalance in Gut Bacteria Is Linked to Fatty Liver Disease and the Potential Role of Probiotics

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Abstract

Gut microbiota dysbiosis significantly contributes to the pathogenesis and severity of nonalcoholic fatty liver disease (NAFLD).

  • The role of gut microbiota in NAFLD is complex and not fully understood.
  • Chemotherapeutic treatments for NAFLD face scrutiny due to potential health side effects.
  • Key mechanisms of gut dysbiosis are linked to the progression of NAFLD and liver cirrhosis.
  • Probiotics have shown promising effects in alleviating gut microbiota dysbiosis.
  • Microbiota-targeted interventions could regulate metabolic pathways to inhibit NAFLD progression.
  • Current human studies on probiotics and NAFLD are very limited, indicating a need for further research.

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