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HSP90, a Capacitor of Behavioral Variation
HSP90's role in controlling differences in behavior
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Abstract
A partial loss of HSP90 function leads to increased behavioral variability in Drosophila.
- HSP90 is implicated in the circadian control of behavior.
- Mutations or pharmacological inhibition of HSP90 do not disrupt the circadian clock.
- Instead, HSP90 affects how molecular oscillations translate into behavioral rhythms.
- HSP90-deficient flies exhibit less consistent behavioral activity patterns.
- Reduced HSP90 activity is associated with greater behavioral variability both across individuals and within the lifespan of a single fly.
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