Pharmaceutical research

Impurities and Possible Immune Reactions Linked to Generic and Mixed Versions of Glucagon-like Peptide-1 Receptor Agonists

Updated

Abstract

The assessment focused on impurity profiles and potential immunogenicity of follow-on or compounded products for two GLP-1 receptor agonists: semaglutide and liraglutide.

  • Multiple samples of semaglutide and liraglutide were evaluated.
  • The study aimed to identify impurity profiles associated with these products.
  • Potential immunogenicity of the samples was also assessed.
  • Findings may inform safety and efficacy considerations for these glucagon-like peptide-1 receptor agonists.

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Funding

Competing interests

Declarations. Conflicts of Interest: K.L.K., K.L., O.S., A.K.Ø., M.W., J.E.M., H.S.R.-A., C.L.S., and M.H. are employees and shareholders of Novo Nordisk A/S. A.S. is a shareholder of Novo Nordisk A/S and was an employee of Novo Nordisk A/S at the time that this study was undertaken.
PubMed

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