An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks

Dec 27, 2016Current biology : CB

A Gene Network Controlled by LHX1 Regulates Sleep-Wake Timing and Temperature Resistance in the Body's Central Clock

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Abstract

Loss of LHX1 results in impaired acute light control of sleep and temperature resistance in mice.

  • LHX1 influences circadian functions independently of the neuropeptide vasoactive intestinal peptide (VIP).
  • Lhx1-deficient mice exhibit a loss of acute light control of sleep compared to VIP-deficient mice.
  • Lhx1-deficient mice show a diminished resistance to fever, indicating a role of LHX1 in temperature regulation.
  • A transcriptional network downstream of LHX1 was identified that operates independently of VIP.
  • This VIP-independent network does not impact core clock amplitude and synchrony.

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