‘Life’s Essential 8’ cardiovascular health with premature cardiovascular disease and all-cause mortality in young adults: the Kailuan prospective cohort study

Among 16,011 CVD-free participants aged 18-40, 1.7% developed cardiovascular disease during a median follow-up of 13 years.

• Lower cardiovascular health (CVH) scores were associated with a higher risk of both premature cardiovascular disease (CVD) and all-cause mortality.
• The hazard ratio for developing CVD in individuals with low CVH compared to high CVH was 7.34 at baseline.
• For all-cause mortality, the hazard ratio for low CVH versus high CVH was 2.54 at baseline.
• Time-updated CVH scores showed a hazard ratio of 4.38 for CVD and 1.99 for all-cause mortality in the low CVH group compared to high.
• Time-varying CVH demonstrated an even stronger association, with a hazard ratio of 8.19 for CVD and 4.28 for all-cause mortality in the low CVH group.
• Among the eight metrics of Life's Essential 8, lower scores in health factors were linked to increased risks, while health behaviors did not show significant associations.

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