Association of Life's Essential 8 with all-cause and cardiovascular mortality among US adults: A prospective cohort study from the NHANES 2005–2014

Feb 12, 2023Nutrition, metabolism, and cardiovascular diseases : NMCD

Links between Life's Essential 8 health factors and death from any cause or heart disease in US adults

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Abstract

A higher Life's Essential 8 (LE8) score is associated with a 40% reduction in the risk of all-cause mortality among US adults.

Participants with a high LE8 score (80-100) had a 40% lower risk of all-cause mortality compared to those with a low score (0-49).
A 10-point increase in LE8 score is linked to a 14% lower risk of all-cause mortality.
The risk of cardiovascular mortality decreased by 54% in individuals with high CVH compared to those with low CVH.
During a median follow-up of 113 months, 2,942 deaths were recorded, including 738 from cardiovascular disease.
The study included 23,110 participants aged 20 years or older, with a weighted mean age of 47 years.

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BACKGROUND AND AIMS: This study aims to investigate the association of Life's Essential 8 (LE8), the recently updated algorithm for quantifying cardiovascular health (CVH) by the American Heart Association (AHA), with long-term outcomes among US adults.

METHODS AND RESULTS: This population-based prospective cohort study analyzed data of 23,110 participants aged 20 years or older from the National Health and Nutrition Examination Survey from 2005 to 2014 and their linked mortality data through December 2019. LE8 score (range 0-100) was measured according to AHA definitions and was categorized into low (0-49), moderate (50-79), and high (80-100) CVH. The weighted mean age of the study population was 47.0 years (95% confidence interval [CI], 46.4-47.5 years), and 11,840 were female (weighted percentage, 51.5%; 95% CI, 50.9-52.1%). During a median follow-up period of 113 months (up to 180 months), 2942 all-cause deaths occurred, including 738 CVD deaths. The LE8 score was significantly and inversely related to mortality from all causes (adjusted hazard ratio [HR] for per 10-score increase in LE8 score, 0.86; 95% CI, 0.82-0.90) and cardiovascular disease (adjusted HR for per 10-score increase in LE8 score, 0.81; 95% CI, 0.75-0.87). Compared with participants having low CVH, those having high CVH had a reduction of 40% (adjusted HR, 0.60; 95% CI, 0.48-0.75) in the risk for all-cause mortality and 54% (adjusted HR, 0.46; 95% CI, 0.31-0.68) in the risk for cardiovascular mortality.

CONCLUSIONS: Higher LE8 score was independently associated with lower risks of all-cause and cardiovascular mortality among US adults.

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Association of Life's Essential 8 with all-cause and cardiovascular mortality among US adults: A prospective cohort study from the NHANES 2005–2014

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