Magic truffles or Philosopher's stones: a legal way to sell psilocybin?

The content of psilocybin in examined Psilocybe sclerotia ranged from 59.3 to 167.8 µg per 100 mg.

• A liquid chromatography-tandem mass spectrometry method was developed for detecting psilocybin and psilocin in magic truffles.
• Detection limits were established at 0.3 µg and quantification limits at 1 µg per 100 mg of truffles for both substances.
• The method demonstrated linearity for both psilocybin and psilocin with a correlation coefficient greater than 0.99.
• Only psilocybin was found in the examined Psilocybe sclerotia.
• The variability in psilocybin content suggests potential differences in potency among different batches of sclerotia.

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