Melatonin as a New Treatment for Reducing Chronic Pain and Pain from Sleep Disorders

Melatonin is produced in most living organisms and plays a critical role in regulating circadian rhythms.

• Endogenous melatonin contributes to circadian rhythms in diurnal animals but not in nocturnal animals.
• Circadian rhythms influence the timing and secretion of hormones and neurotransmitters.
• Disturbances in circadian rhythms can lead to abnormal production of hormones and chemicals.
• The human circadian system aligns with physiological functions and metabolism.
• Exogenous melatonin has been reported to have analgesic and neuroprotective effects in chronic pain.
• Chronotherapy utilizing melatonin may be advantageous in treating chronic pain.

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