Clinical significance of melatonin receptors in the human myometrium

Jul 13, 2014Fertility and sterility

Importance of Melatonin Receptors in the Human Uterine Muscle

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Abstract

Melatonin acts through the MTNR1B receptor to enhance uterine contractions at late term.

  • The MTNR1B melatonin receptor is expressed in the myometrium during late-term pregnancy.
  • Melatonin may synergistically enhance signaling and contractions that depend on oxytocin.
  • Acute exposure to white light could reversibly suppress uterine contractions by inhibiting melatonin levels.
  • These findings suggest a significant role for circulating melatonin in regulating uterine contractions.

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