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Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure
Predicting how light affects melatonin in humans using brightness, color, timing, and length of exposure
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Abstract
Melatonin suppression is primarily influenced by four light exposure characteristics: melanopic equivalent daylight illuminance (EDI), light exposure duration, pupil dilation, and S-cone-opic EDI.
- serves as a strong predictor of melatonin suppression, particularly at higher light levels.
- Light exposure duration is a significant factor affecting the extent of melatonin suppression.
- Pupil dilation is associated with increased melatonin suppression in various light conditions.
- S-cone-opic EDI is an important factor for melatonin suppression at photopic illuminances below 21 lux.
- The findings provide initial guidance for lighting practitioners on optimizing light exposure to manage non-visual responses.
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Key numbers
15.19%
Best Predictor of
Lowest RMSE achieved with four predictors including .
208 lx
ED50 for Undilated Pupils
Estimated for undilated pupils based on model predictions.
72 lx
ED50 for Dilated Pupils
Significantly lower than the value for undilated pupils.