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On the Mode of Action of Methionine Enkephalin, FK 33-824 and Naloxone in Regulating the Hemolymph Glucose Level in the Fresh Water Field Crab Oziotelphusa senex senex
How Methionine Enkephalin, FK 33-824, and Naloxone Affect Blood Sugar Levels in Freshwater Crabs
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Abstract
Injection of the opioid methionine-enkephalin significantly elevated hemolymph glucose levels in the freshwater crab Oziotelphusa senex senex.
- Opioid agonist and antagonist treatments were applied to investigate their effects on glucose levels.
- Methionine-enkephalin and FK 33-824 injections led to a notable increase in hemolymph glucose.
- Naloxone injections resulted in a decrease in hemolymph glucose levels.
- Naloxone blocked the glucose-increasing effect of methionine-enkephalin when given beforehand.
- No significant changes in glucose levels were observed in eyestalk-less crabs after injecting methionine-enkephalin, FK 33-824, or naloxone.
- The findings suggest that glucose level alterations are likely linked to hormone release stimulated by methionine-enkephalin and FK 33-824 and inhibited by naloxone.
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