General and comparative endocrinology

Retinoic acid's effect on blood sugar control in the freshwater edible crab Oziotelphusa senex senex

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Updated

Abstract

Injection of 9-cis-retinoic acid (9CRA) significantly increased hemolymph glucose levels in crabs.

  • 9CRA induced hyperglycemia in intact crabs in a dose-dependent manner.
  • The hyperglycemic effect of 9CRA was associated with the crustacean hyperglycemic hormone (CHH).
  • Eyestalk-ablated crabs did not exhibit hyperglycemia following 9CRA injection.
  • 9CRA administration resulted in reduced hyperglycemic activity of eyestalks and elevated CHH levels in hemolymph.
  • All-trans-retinoic acid (ATRA) did not alter hemolymph glucose or CHH levels.

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