Effect of retinoic acid on hemolymph glucose regulation in the fresh water edible crab Oziotelphusa senex senex

Oct 30, 2007General and comparative endocrinology

Retinoic acid's effect on blood sugar control in the freshwater edible crab Oziotelphusa senex senex

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Abstract

Injection of 9-cis-retinoic acid (9CRA) significantly increased hemolymph glucose levels in crabs.

9CRA induced hyperglycemia in intact crabs in a dose-dependent manner.
The hyperglycemic effect of 9CRA was associated with the crustacean hyperglycemic hormone (CHH).
Eyestalk-ablated crabs did not exhibit hyperglycemia following 9CRA injection.
9CRA administration resulted in reduced hyperglycemic activity of eyestalks and elevated CHH levels in hemolymph.
All-trans-retinoic acid (ATRA) did not alter hemolymph glucose or CHH levels.

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9-cis-Retinoic acid (9CRA) and all-trans-retinoic acid (ATRA) are known to be involved in the regulation of glucose homeostasis in vertebrates by inducing insulin release and expression of glucose reporter proteins. In view of the fact that 9CRA and ATRA are endogenous in crustaceans and a retinoic acid X-receptor exists in crabs, we investigated whether 9CRA and ATRA also plays a role in glucose homeostasis in freshwater crab, Oziotelphusa senex senex. Injection of 9CRA into intact crabs significantly increased the hemolymph glucose level in a dose-dependent manner. Such 9CRA-induced hyperglycemia was apparently mediated by the CHH since injection of 9CRA into eyestalk-ablated crabs did not result in hyperglycemia. In support of this, administration of 9CRA in to crabs resulted in reduced hyperglycemic activity of eyestalks and elevated titers of CHH in hemolymph. ATRA injection did not cause any changes in hemolymph glucose and CHH levels. The results provide the first evidence that 9-cis-retinoic acid, but not all-trans-retinoic acid, is involved in the regulation of glucose homeostasis and apparently mediated by the eyestalk hormone CHH.

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Effect of retinoic acid on hemolymph glucose regulation in the fresh water edible crab Oziotelphusa senex senex

Abstract

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