United European gastroenterology journal

Changes in Tissue and Immune Molecules in the Small Intestine and Surrounding Area Before and After Surgery in Crohn's Disease

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Updated

Abstract

68 samples from 34 patients with Crohn's disease showed improved microbial health in the ileal mucosa and mesentery after ileocecal resection.

  • Ileocecal resection is associated with positive changes in the microbial composition of the ileal mucosa and mesentery in patients with Crohn's disease.
  • Spatial alterations in microbiota and metabolites were detected before and after surgery.
  • Differentially expressed metabolites in the ileal mucosa and mesentery were analyzed for their biological significance.
  • The findings suggest a multi-omics approach may enhance understanding of treatment mechanisms for Crohn's disease.

Simplified

Key numbers

< 0.001
Decrease in Microbial Dysbiosis Index
Comparison of MDI scores before and after ileocecal resection.
310
Metabolites Identified
Number of metabolites significantly upregulated in the active stage.
2470
Common Metabolites
Total metabolites shared between active and remission stages.

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Funding

Competing interests

The authors declare no conflicts of interest.
PubMed

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