Advances and Challenges in Nano-Delivery Systems for Glioblastoma Treatment: A Comprehensive Review

Aug 11, 2025International journal of nanomedicine

Progress and Challenges in Tiny Particle Delivery Systems for Treating Brain Cancer

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Abstract

Nanotechnology may enhance the delivery and effectiveness of therapies for glioblastoma.

Glioblastoma is characterized as the most aggressive and lethal primary brain tumor in adults.
Current treatments provide limited survival benefits due to challenges like the and tumor heterogeneity.
Nanotechnology offers a platform to improve the delivery and specificity of therapeutic agents.
Nanoscale systems may help overcome biological and pharmacological barriers in glioblastoma treatment.
Recent strategies in nanomedicine show promise but face challenges to clinical translation.

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Glioblastoma is the most aggressive and lethal primary brain tumor in adults, with current treatment options offering only limited improvement in patient survival. Despite the advancement of modalities such as immunotherapy, targeted therapy, gene therapy, focused ultrasound, and tumor-treating fields, therapeutic efficacy remains unsatisfactory due to challenges such as the , tumor heterogeneity, and treatment resistance. Nanotechnology has emerged as a promising platform to enhance the delivery, specificity, and combinatorial potential of these therapies. By enabling precise and multifunctional delivery of therapeutic agents, nanoscale systems hold the potential to overcome critical biological and pharmacological barriers in glioblastoma treatment. This review provides an overview of recent progress in nanomedicine-based strategies for glioblastoma, critically examines the key challenges that limit their clinical translation, and highlights innovative approaches designed to improve therapeutic outcomes. Future perspectives on how nanotechnology may reshape the landscape of brain tumor treatment are also discussed.

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Advances and Challenges in Nano-Delivery Systems for Glioblastoma Treatment: A Comprehensive Review

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