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Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms
Neurons that produce Neuromedin S help the brain’s internal clock cells work together and control daily rhythms
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Abstract
A subset of neurons in the suprachiasmatic nucleus expressing neuromedin S (NMS) is essential for daily behavioral rhythms.
- Lengthening the period within NMS neurons can extend the period of the suprachiasmatic nucleus (SCN) and associated behavioral rhythms.
- Mice lacking a functional molecular clock in NMS neurons exhibit no synchronous molecular oscillations or coherent daily rhythms.
- Despite the absence of NMS and its related paralog Nmu, mice maintain in vivo circadian rhythms.
- Disruption of vesicular transmission from NMS neurons affects SCN timing mechanisms, indicating their role in network synchrony.
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