New understanding of how core body clock proteins are controlled without changing gene activity

Mammalian circadian rhythms drive ∼24 h periodicity in various cellular processes.

• Circadian rhythms coordinate physiology and behavior within organisms.
• The core timekeeping mechanism involves a delayed negative-feedback loop with specific proteins.
• Key proteins include the CLOCK-BMAL1 complex and several repressors.
• Recent findings emphasize the importance of post-transcriptional and post-translational modifications.
• Understanding these non-transcriptional events may enhance the knowledge of circadian timekeeping.

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