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Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?
Nonalcoholic Fatty Liver Disease: Can Changing Gut Bacteria Improve Its Severity?
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Abstract
Clinical guidelines recommend a weight loss goal of 7%-10% to improve features of nonalcoholic fatty liver diseases.
- Gut microbiota may influence the development of metabolic diseases through the gut-liver axis.
- Probiotics, prebiotics, synbiotics, fecal microbiota transfer, polyphenols, specific diets, and exercise interventions may alter gut microbiota and improve nonalcoholic fatty liver disease outcomes.
- Most potential therapeutic options have predominantly been studied in animal models rather than humans.
- Efficacy of these gut microbiota-modulating therapies is not yet confirmed in human trials.
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