Nuclear receptor Rev-erbα: up, down, and all around

Rev-erbα is a transcriptional repressor that connects circadian rhythms to metabolic regulation.

• Rev-erbα is crucial for maintaining the core mammalian molecular clock.
• It regulates clock output in metabolic tissues such as the liver and brown adipose tissue.
• Rev-erbα and its paralog Rev-erbβ contribute to rhythm generation and may influence energy expenditure.
• These proteins are associated with additional regulatory roles in inflammation and behavior.
• Targeting Rev-erbα and β pathways may offer therapeutic potential for human diseases.

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