Effects of physical exercise on myokines expression and brown adipose-like phenotype modulation in rats fed a high-fat diet

Exercise training increased bone morphogenetic protein 7 (BMP7) and other proteins associated with browning in white adipose tissue of rats fed a high-fat diet.

• Hypertrophy of fat cells caused by a high-fat diet was reduced by voluntary physical activity and exercise training.
• High-fat diet decreased activity of a key energy-sensing protein in muscle and reduced specific proteins related to fat metabolism in white adipose tissue.
• Voluntary physical activity elevated levels of a specific gene associated with fat cell function in rats on a standard diet.
• Exercise training enhanced the expression of proteins linked to energy metabolism in muscle, but did not change levels of circulating irisin.
• Exercise training resulted in increased expression of proteins associated with a 'brown-like' fat phenotype in white adipose tissue, particularly in standard diet-fed rats.

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