Post-illumination Pupil Response in Subjects without Ocular Disease

All 37 subjects displayed a positive post-illumination pupil response (PIPR) to a 10-second, 470-nm light stimulus.

• The average PIPR for 470-nm light was 1.5 mm, indicating a substantial response in the tested population.
• A net PIPR of 1.4 mm was observed when comparing responses to blue and red light stimuli.
• The net PIPR showed a positive correlation with baseline pupil diameter.
• No significant correlation was found between net PIPR and age, race, or sex in the study sample.
• The findings support the involvement of melanopsin in mediating the PIPR, as evidenced by the significant response to blue light but not red.

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