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Remimazolam versus propofol for postoperative delirium prevention in geriatric surgery: A systematic review and meta-analysis of randomized controlled trials
Remimazolam versus propofol and their links to preventing confusion after surgery in older adults
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Abstract
The meta-analysis included five randomized controlled trials with 1,368 patients.
- No statistically significant difference in postoperative delirium incidence was found between remimazolam and propofol (risk ratio = 0.88).
- Remimazolam was associated with a significant reduction in hypotensive events (risk ratio = 0.55).
- There were no differences between the groups regarding postoperative nausea and vomiting incidence.
- Results suggest that remimazolam does not increase the risk of postoperative delirium in elderly surgical patients.
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Key numbers
0.88
Postoperative Delirium Incidence Risk Ratio
POD incidence risk ratio comparing remimazolam vs. propofol groups.
0.55
Hypotensive Events Risk Ratio
Risk ratio for hypotensive events in remimazolam vs. propofol groups.
1,368
Total Patients Included
Total number of patients in the meta-analysis.