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Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes
Resveratrol may protect liver cells from acrylamide damage by targeting internal body clock regulators to reduce mitochondrial problems and inflammation
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Abstract
Resveratrol pretreatment prevented acrylamide-induced cell death and mitochondrial dysfunction in liver cells.
- Acrylamide disrupts circadian gene transcription and protein expression, including Bmal1 and Cry1, in liver cells.
- Resveratrol effectively mitigates acrylamide-triggered oxidative damage and inflammatory responses in HepG2 liver cells.
- The protective effects of resveratrol on mitochondrial function are linked to the activation of the Nrf2/NQO-1 pathway.
- The benefits of resveratrol in counteracting inflammation are associated with the Cry1 protein.
- Findings suggest that resveratrol could help in managing acrylamide's hepatotoxic effects and maintaining circadian rhythm.
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