Resveratrol may protect liver cells from acrylamide damage by targeting internal body clock regulators to reduce mitochondrial problems and inflammation

Resveratrol pretreatment prevented acrylamide-induced cell death and mitochondrial dysfunction in liver cells.

• Acrylamide disrupts circadian gene transcription and protein expression, including Bmal1 and Cry1, in liver cells.
• Resveratrol effectively mitigates acrylamide-triggered oxidative damage and inflammatory responses in HepG2 liver cells.
• The protective effects of resveratrol on mitochondrial function are linked to the activation of the Nrf2/NQO-1 pathway.
• The benefits of resveratrol in counteracting inflammation are associated with the Cry1 protein.
• Findings suggest that resveratrol could help in managing acrylamide's hepatotoxic effects and maintaining circadian rhythm.

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