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Acrylamide Defects the Expression Pattern of the Circadian Clock and Mitochondrial Dynamics in C57BL/6J Mice Liver and HepG2 Cells
Acrylamide alters daily rhythm and energy control in mouse liver and human liver cells
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Abstract
Acrylamide significantly induced circadian gene oscillation disorder and blocked circadian-related protein expression in mice liver.
- Acrylamide treatment disrupted the normal rhythmic patterns of circadian genes in the liver.
- The levels of circadian-related proteins were notably reduced following exposure to acrylamide.
- Daily oscillation of antioxidant enzymes was negatively affected by acrylamide treatment.
- Acrylamide increased the expression of genes related to mitochondrial dynamics and altered mitochondrial shape during the night phase.
- Acrylamide may inhibit circadian protein expression by affecting the phosphorylation of AKT and increasing oxidative stress.
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