Journal of agricultural and food chemistry

Acrylamide alters daily rhythm and energy control in mouse liver and human liver cells

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Acrylamide significantly induced circadian gene oscillation disorder and blocked circadian-related protein expression in mice liver.

  • Acrylamide treatment disrupted the normal rhythmic patterns of circadian genes in the liver.
  • The levels of circadian-related proteins were notably reduced following exposure to acrylamide.
  • Daily oscillation of antioxidant enzymes was negatively affected by acrylamide treatment.
  • Acrylamide increased the expression of genes related to mitochondrial dynamics and altered mitochondrial shape during the night phase.
  • Acrylamide may inhibit circadian protein expression by affecting the phosphorylation of AKT and increasing oxidative stress.

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