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Scalable Hybrid Synthetic/Biocatalytic Route to Psilocybin
A scalable method combining chemical and biological steps to produce psilocybin
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Abstract
One gram of was produced from psilocin within 20 minutes using the mushroom enzyme .
- The problematic phosphorylation step in psilocybin synthesis was replaced with an enzymatic process.
- Recombinant PsiK was produced in a pilot-scale protocol, yielding 150 mg of active and soluble enzyme.
- This method combines the ease of tryptamine chemistry with the precision of enzymatic reactions.
- The approach may facilitate access to psilocybin as a medication for treatment-resistant depression.
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Key numbers
20 min
Production Time
Time taken to produce from psilocin using .
150 mg
Enzyme Yield
Amount of active produced in pilot-scale protocol.