SurgeryAug 25, 2018

Long-term weight changes and health results after sleeve gastrectomy compared to similar gastric bypass patients in the LABS study

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 6, 2026

Abstract

At year 7, mean weight loss was 23.6% after sleeve gastrectomy compared to 30.4% after Roux-en-Y gastric bypass.

Weight loss was significantly less for participants undergoing sleeve gastrectomy compared to those undergoing Roux-en-Y gastric bypass.
Participants in both surgical groups showed significant reductions in diabetes, low high-density lipoprotein levels, and hypertension after 5 years.
The study included a matched sample of 57 participants who underwent sleeve gastrectomy and Roux-en-Y gastric bypass.
Most participants were female (68%), white (81%), with a median age of 49 years and a median body mass index of 56.4 kg/m² before surgery.

Simplified

BACKGROUND: Data from a US multicenter longitudinal study of bariatric surgery were used to compare weight change (primary outcome) and comorbidities (secondary outcome) in patients who underwent sleeve gastrectomy versus Roux-en-Y gastric bypass.

METHODS: This study includes participants who underwent sleeve gastrectomy and matched participants who underwent Roux-en-Y gastric bypass from the Longitudinal Assessment of Bariatric Surgery-2 (LABS-2) study. Adults undergoing initial bariatric surgical procedures between 2006 and 2009 were enrolled. Participants who underwent sleeve gastrectomy were high-risk or superobese and intended to have a second-stage procedure. Mixed models were used to evaluate percent weight change from baseline through 7 years, and diabetes, dyslipidemia, and hypertension prevalence through 5 years.

RESULTS: Fifty-seven of 59 participants who underwent sleeve gastrectomy were matched one to one. Most were female (68%) and white (81%), and had a median age of 49 (37-56) years and median body mass index of 56.4 (35.5-76.8) kg/mpresurgery. Weight loss was significantly less 1 to 7 years after sleeve gastrectomy versus matched Roux-en-Y gastric bypass (eg, year 7 mean weight loss was 23.6% vs 30.4%, respectively; P = .001). For both surgical groups, prevalence of diabetes, low high-density lipoprotein, and hypertension were significantly (P < .05) lower 5 years postsurgery versus baseline. 2

CONCLUSION: Higher-risk or super-obese participants after sleeve gastrectomy lost less weight than did matched Roux-en-Y gastric bypass counterparts throughout 7 years. Both groups exhibited improvements in comorbidities from presurgery through 5 years.

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Long-term weight changes and health results after sleeve gastrectomy compared to similar gastric bypass patients in the LABS study

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