Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin

Mar 24, 2017Biogerontology

Daily rhythms of Socs1 change with aging in body clocks of male rats and may improve with melatonin

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Abstract

At 24 months of age, male Wistar rats showed a significant decrease in rSocs1 levels and loss of circadian rhythms in the intestine.

  • Daily rhythms of rSocs1 gene expression were observed in liver, kidney, intestine, and heart of 3-month-old rats.
  • Aging to 12 months led to a 12-hour phase advance in liver rhythms and a 12-hour phase delay in kidney and heart rhythms, with loss of intestinal rhythms.
  • At 24 months, liver and heart showed a 6-hour phase advance, while intestinal rhythms were abolished and kidney rSocs1 levels significantly decreased.
  • Aging is associated with decreased melatonin levels, which may contribute to reduced immunity and increased oxidative stress.
  • Exogenous melatonin treatment partially restored rSocs1 rhythms in the liver and intestine of 12-month-old rats.
  • Melatonin administration significantly increased mean 24-hour rSocs1 expression in the intestine and heart of 24-month-old rats compared to 3-month-olds.

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