Detailed gene activity map of the human brain’s internal clock control center

A human suprachiasmatic nucleus atlas mapped seven neuron subtypes and suggests an AVP/NMS subtype may relate to morningness chronotype.

This atlas study combined human spatial transcriptomics, single-nucleus RNA sequencing, deep-learning histology, cross-species comparisons, and GWAS integration in the adult human SCN.

Because this is an atlas and integrative association study, it maps cell types and candidate links but does not functionally prove chronotype mechanisms.