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Synaptic Targets of Circadian Clock Neurons Influence Core Clock Parameters
Connections of Body Clock Neurons Affect Main Clock Functions
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Abstract
Silencing synaptic output in SLP316 neurons shortens the free-running period of circadian rhythms.
- The circadian clock network relies on neuronal connectivity for effective timekeeping.
- sLNs release the neuropeptide PDF, critical for their role as pacemakers.
- Connectomic analyses identified strong synaptic connections between sLNs and SLP316 neurons.
- Silencing SLP316 neurons leads to reduced daytime activity and increased daytime sleep.
- Hyper-exciting SLP316 neurons extends the free-running period of circadian rhythms.
- SLP316 neurons, while non-clock cells, play a role in regulating sleep and activity timing.
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