We can’t show the full text here under this license.
Daily patterns of gene activity and body functions in mammals
Updated
Abstract
Chronic disruption of daily rhythms may lead to increased morbidity and reduced lifespan.
- Mammalian behavior and physiology are regulated by an endogenous circadian timing system.
- A master pacemaker in the coordinates peripheral oscillators throughout the body.
- Genome-wide studies have identified hundreds of genes that are rhythmically expressed in various tissues.
- These cyclic gene expressions influence sleep-wake cycles, metabolism, detoxification, and cell growth.
- Disruption of this temporal organization could have significant health consequences.
Simplified