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The daily timing of gene expression and physiology in mammals
Daily patterns of gene activity and body functions in mammals
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Abstract
Chronic disruption of daily rhythms may lead to increased morbidity and reduced lifespan.
- Mammalian behavior and physiology are regulated by an endogenous circadian timing system.
- A master pacemaker in the coordinates peripheral oscillators throughout the body.
- Genome-wide studies have identified hundreds of genes that are rhythmically expressed in various tissues.
- These cyclic gene expressions influence sleep-wake cycles, metabolism, detoxification, and cell growth.
- Disruption of this temporal organization could have significant health consequences.
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