Time-restricted feeding mitigates obesity through adipocyte thermogenesis

Genetic enhancement of adipocyte thermogenesis attenuated obesity in mice consuming a high-fat diet during the inactive period.

• Misalignment of feeding rhythms with the light-dark cycle is linked to disrupted circadian clocks and obesity.
• Restricting feeding to the active period may reduce metabolic syndrome through unknown mechanisms.
• Ablation of the zinc finger protein 423 (ZFP423) increased futile creatine cycling in adipocytes.
• Circadian control of adipocyte creatine metabolism is associated with the timing of diet-induced thermogenesis.
• Overexpression of the clock activator BMAL1 improved metabolic complications during diet-induced obesity.

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