It’s All in the Timing: Many Clocks, Many Outputs

Circadian regulation involves a master clock in the SCN that synchronizes body rhythms.

• The master clock consists of interlocking feedback loops that control core clock genes essential for maintaining the oscillator.
• Specific output genes are regulated by the master clock and mediate physiological processes influenced by circadian rhythms.
• Both neuroanatomic and molecular outputs from the clock are necessary for its proper function.
• Recent advancements in technology have enhanced understanding of the SCN's anatomic outputs.
• Molecular outputs from both central and peripheral oscillators are linked to observed physiological changes.

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