Circulation

Tirzepatide's effects on health outcomes in obese patients with heart failure and normal heart pumping

Updated

Abstract

Tirzepatide increased the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score by 6.9 points at 52 weeks.

  • Compared with placebo, tirzepatide was associated with a consistent beneficial effect on the combined risk of cardiovascular death or worsening heart failure events.
  • Tirzepatide improved the 6-minute walk distance by 18.3 meters and the EQ-5D-5L health state index by 0.06.
  • Patients receiving tirzepatide reported a more favorable overall health score and improved New York Heart Association class.
  • The use of heart failure medications was lower in the tirzepatide group compared to placebo.
  • A hierarchical composite analysis indicated a broad spectrum of benefits associated with tirzepatide treatment.

Simplified

Key numbers

0.41–0.67
Decrease in cardiovascular death or worsening heart failure events
Hazard ratios for composite cardiovascular outcomes.
6.9 points
Increase in
Between-group difference at 52 weeks compared to placebo.
18.3 m
Increase in
Between-group difference at 52 weeks compared to placebo.

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Funding

Competing interests

Dr Zile receives research support from the Department of Veterans Affairs (projects BX005943 and BX005848) and serves as a consultant for Abbott, Adona Medical, Aria CV, Avery Therapeutics, Inc, Boehringer-Ingelheim, Boston Scientific, Cardiovascular Research Foundation Clinical Trials Center, CVRx, DIASTOL Therapeutics, LLC, EBR, Edwards, Lilly, GenKardia, Innoventric, KestraMedical, Medtronic, Merck, Morphic Therapeutics, Novartis, Pulnova, Salubris Biotherapeutics, Sonata, SRNALYTICS, INC, V-WAVE, and Vectorious. Dr Borlaug receives research support from the National Institutes of Health (R01 HL128526, R01 HL162828, and U01 HL160226 from the National Heart, Lung, and Blood Institute) and the US Department of Defense, as well as research grant funding from AstraZeneca, Axon, Corvia, Novo Nordisk, and Tenax Therapeutics. Dr Borlaug has served as a consultant for Actelion, Amgen, Aria, Axon Therapies, BD, Boehringer Ingelheim, Cytokinetics, Edwards Lifesciences, Lilly, Imbria, Janssen, Merck, Novo Nordisk, NGM, NXT, and VADovations. Dr Borlaug is named inventor (US Patent No. 10 307 179) for the tools and approach for a minimally invasive pericardial modification procedure to treat heart failure. Dr Kramer has served as a consultant for and received research grants from Lilly and has received research grants from Cytokinetics and Bristol Meyers Squibb. Dr Baum has served as consultant for Altimmune, Amgen, Beren Therapeutics, Boehringer Ingelheim, Lilly, Esperion, Ionis Pharmaceuticals, Madrigal Pharmaceuticals, Merck, Novartis, and Regeneron. Dr Litwin reports being on the patient selection committee for Corvia and Axon and being a consultant for Novo Nordisk and Lilly. Dr Menon reports no conflicts. Drs Ou, Weerakkody, Hurt, Kanu, and Murakami are employed by Eli Lilly and Company. Dr Packer has served as a consultant for 89bio, Abbvie, Actavis, Altimmune, Alnylam, Amarin, Amgen, Ardelyx, ARMGO, AstraZeneca, Attralus, Biopeutics, Boehringer Ingelheim, Caladrius, Casana, CSL Behring, Cytokinetics, Lilly, Imara, Medtronic, Moderna, Novartis, Pharmacocosmos, Reata, Regeneron, Roche, and Salamandra.
PubMed

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