Longevity & Aging Clinical Trials and Studies

5 months ago • Journal of translational medicine

Low-dose rapamycin may reduce fatigue and post-exertion worsening in ME/CFS by improving cell cleanupLow-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study

🥉 Top 5% JournalFulltext (Open License)Multicenter Study

1 month ago • Aging cell

A Lifestyle Program Linked to Better Daily Function and Slower Biological Aging in Frail Older AdultsA Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial

🥉 Top 5% JournalFulltext (Open License)Randomized Controlled Trial

6 months ago • Nutrients

Pomegranate Extract’s Effects on Growth Factor Levels and Cell Aging in Adults Aged 55-70: Results from a Controlled TrialEffects of Pomegranate Extract on IGF-1 Levels and Telomere Length in Older Adults (55–70 Years): Findings from a Randomised Double-Blinded Controlled Trial

🎖️ Top 10% JournalFulltext (Open License)Randomized Controlled Trial

1 month ago • Journal of the International Society of Sports Nutrition

Nicotinamide mononucleotide (NMN) may reduce inflammation in human muscles after blood flow–restricted exerciseAnti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise

🎖️ Top 10% JournalFulltext (Open License)Randomized Controlled Trial

4 months ago • Cardiovascular diabetology

Changes in body proteins with organ aging and heart-related health risks in people at risk for heart failureProteome organ aging and cardiometabolic risk in a population at risk for heart failure

🥈 Top 2% JournalMulticenter Study

2 months ago • Journal of extracellular vesicles

Blood Metabolites May Treat Jaw Joint Osteoarthritis by Removing Aged Cartilage Cells Through the C1QBP/C1q/p14ARF PathwayCirculating Metabolites Treat Human TMJ‐OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis

🥈 Top 2% JournalRandomized Controlled Trial

4 months ago • Journal of the International Society of Sports Nutrition

Dileucine-enhanced essential amino acids help build body tissues after resistance exercise and in cell growth testsDileucine-supplemented essential amino acids support whole-body anabolism after resistance exercise and serum-stimulated cell-based anabolism

🎖️ Top 10% JournalFulltext (Open License)Randomized Controlled Trial

3 months ago • Journal of the peripheral nervous system : JPNS

Nicotinamide Riboside may help prevent small nerve damage and support nerve regrowthEvaluation of Nicotinamide Riboside in Prevention of Small Nerve Fiber Axon Degeneration and Promotion of Nerve Regeneration

📖 Top 20% JournalRandomized Controlled Trial

4 months ago • International journal of molecular sciences

Pigmented Rice Rich in Antioxidants and Anti-Aging Amino Acids May Support Healthy Aging by Reducing Cell Damage and Inflammation: A Randomized Clinical TrialAn Anthocyanin- and Anti-Ageing Amino Acids-Enriched Pigmented Rice Innovation Promotes Healthy Ageing Through the Modulation of Telomere, Oxidative Stress and Inflammation Reduction: A Randomized Clinical Trial

📖 Top 20% JournalFulltext (Open License)Randomized Controlled Trial

4 months ago • Alzheimer's research & therapy

Sleep patterns and body clock rhythms affect chromosome aging in older adults with or without Alzheimer's riskTelomere dynamics are influenced by sleep, sleep variability and circadian rhythms in older adults with or without alzheimer’s risk

🥉 Top 5% JournalRandomized Controlled Trial

5 months ago • Nature aging

Urolithin A may slow age-related immune decline in a controlled trialEffect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

🥇 Top 1% JournalRandomized Controlled Trial

6 months ago • Age and ageing

Two-year cocoa extract use and inflammation-related aging markers in older US adultsEffects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial

🥉 Top 5% JournalRandomized Controlled Trial

5 months ago • Frontiers in immunology

Changes over time in cancer rates and outcomes in kidney transplant patients from 2000-2010 to 2010-2021Temporal trends in malignancy incidence and outcomes among kidney transplantation recipients: a multi-center real-world evidence study using the TriNetX network (2000–2010 vs. 2010–2021)

🥉 Top 5% JournalFulltext (Open License)Multicenter Study

2 months ago • Lancet (London, England)

Using an AI-powered stethoscope to detect three heart and blood vessel diseases in the UK: a group-randomized trialTriple cardiovascular disease detection with an artificial intelligence-enabled stethoscope (TRICORDER) in the UK: a cluster-randomised controlled implementation trial

🥇 Top 1% JournalRandomized Controlled Trial

6 months ago • International journal of food sciences and nutrition

Resveratrol raises protective protein levels and reduces frailty in knee osteoarthritis patients in a controlled trialResveratrol treatment increases sirtuin 1 levels and alleviates frailty phenotype in knee osteoarthritis patients: a randomised placebo-controlled clinical trial

📖 Top 30% JournalRandomized Controlled Trial

4 months ago • Journal of the American Heart Association

Epigenetic Aging Measures Linked to New Heart and Blood Vessel Problems in MESA StudyEpigenetic Aging Clocks and Incident Cardiovascular Outcomes: Results From the MESA

🥉 Top 5% JournalMulticenter Study

1 month ago • Journal of drugs in dermatology : JDD

From Anti-Aging to Skin Renewal: Reducing Cell Wear-Out and Aging to Keep Skin Healthy LongerTransitioning from Anti-aging to Skin Activation: Limiting Cellular Fatigue and Senescence for Skin Longevity

📖 Top 30% JournalRandomized Controlled Trial

6 months ago • Nutrients

Four Weeks of Walnut Eating and Its Effects on Oxidative Stress and Inflammation in Middle-Aged Adults with Heart and Metabolic RisksCould 4-Week Walnut Consumption Influence Oxidative and Inflammatory Status in Middle-Aged Adults with Cardiometabolic Risk Factors? Findings from a Randomized Controlled Trial

🎖️ Top 10% JournalFulltext (Open License)Randomized Controlled Trial

6 months ago • Critical care explorations

How Aging Affects Body Responses to Severe Infection: Protein Study in Patients from UgandaAging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda

📖 Top 20% JournalMulticenter Study

1 month ago • Nutrients

Interval resistance and aerobic training with fisetin supplement and their effects on asprosin and fat-related hormones in obese menThe Effects of Interval Resistance—Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial

🎖️ Top 10% JournalFulltext (Open License)Randomized Controlled Trial

3 months ago • Cardiovascular diabetology

Sirtuins and regulatory microRNAs as epigenetic factors in heart recovery after empagliflozin treatment following a heart attackSirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction

🥈 Top 2% JournalRandomized Controlled Trial

3 months ago • Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury

Managing biological age and quality of life using targeted medical rehabilitation methodsEffective management of biological age and quality of life in patients based on the integrated use of pathogenetically focused medical rehabilitation methods

Randomized Controlled Trial

4 months ago • Nutrients

Gut Breakdown Patterns of Plant Compounds Linked to Quality of Life in Postmenopausal WomenPolyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial

🎖️ Top 10% JournalFulltext (Open License)Randomized Controlled Trial

3 months ago • Clinical and translational science

Immune response does not affect how the telomerase inhibitor Imetelstat works or its safety in lower-risk myelodysplastic syndromesNo Effect of Immunogenicity on Pharmacokinetics, Efficacy, and Safety of the Oligonucleotide Telomerase Inhibitor Imetelstat in Lower‐Risk Myelodysplastic Syndromes

📖 Top 20% JournalRandomized Controlled Trial

6 months ago • American journal of cardiovascular drugs : drugs, devices, and other interventions

Nicotinamide Adenine Dinucleotide's effects on heart failure from blocked heart arteries: a randomized, placebo-controlled trialEffect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial

📖 Top 20% JournalRandomized Controlled Trial

4 months ago • European journal of cancer (Oxford, England : 1990)

Adding the UV1 telomerase vaccine to ipilimumab and nivolumab in advanced melanoma: A phase 2 randomized studyThe telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): A randomized open-label phase 2 study

🥉 Top 5% JournalRandomized Controlled Trial

4 months ago • Journal of the International Society of Sports Nutrition

Amino Acids Help Muscle Recovery After ExerciseAmino acid supplementation accelerates resolution of exercise-induced phagocyte infiltration in human skeletal muscle.

🎖️ Top 10% JournalRandomized Controlled Trial

6 months ago • Inflammopharmacology

Resveratrol supplements may improve knee osteoarthritis by increasing a protective proteinResveratrol supplementation improves functional performance in knee osteoarthritis by upregulating sirtuin 1: a randomized study

📖 Top 20% JournalRandomized Controlled Trial

4 months ago • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Fan use may improve cell cleanup and stress responses during long extreme heat exposure in older adultsThe efficacy of fan use on autophagy and the cellular stress response during prolonged exposure to extreme heat in older adults: a randomized trial

Randomized Controlled Trial

5 months ago • Romanian journal of ophthalmology

Lowering the risk of age-related vision loss over five years in Ukraine and MoldovaReducing the risk of age-related macular degeneration progression - five-year follow-up study in Ukraine and Moldova

Multicenter Study