Crosstalk Between Aging, Circadian Rhythm, and Melatonin

Oct 17, 2023Rejuvenation research

Interactions Between Aging, Body Clock, and Melatonin

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Circadian rhythm disruption is indicative of the aging process.

  • Circadian rhythms are governed by an internal clock located in the suprachiasmatic nucleus.
  • Melatonin synthesis decreases with age, potentially leading to circadian rhythm disruption.
  • Older individuals may experience more frequent disruptions in their circadian rhythms.
  • Understanding the relationship between circadian rhythms and aging could improve treatments for age-related disorders.
  • Melatonin plays a key role in regulating the circadian pacemaker and maintaining cellular balance during aging.
  • Exogenous melatonin supplementation may help mitigate age-related circadian rhythm disruption.

AI simplified

Full Text

Full text is available at the source.
View full text (XML) ↗View full text (PDF) ↗View full text ↗

Related papers

Sep '11
Melatonin as both a main clock signal and an internal timekeeper in the body’s daily rhythm system
cited by 287 papers
research support, non-u.s. gov't
Mar '14
Melatonin’s role in fixing age-related changes in daily patterns of clock gene activity in the brain’s timekeeping center of male rats
top 20% journal
cited by 56 papers
research support, non-u.s. gov't
Jun '11
Body Clock and Its Role in Digestive System Rhythms
top 50% journal
cited by 120 papers
research support, non-u.s. gov't
Feb '05
The human pineal gland and melatonin levels in aging and Alzheimer's disease
top 5% journal
cited by 293 papers
research support, non-u.s. gov't
May '06
Melatonin's role in the multiple internal clocks of mammals
top 30% journal
cited by 76 papers
research support, non-u.s. gov't
Jan '96
Melatonin's daily effects on the brain's internal clock
top 20% journal
cited by 92 papers
research support, u.s. gov't, p.h.s.

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #35
Bacteria exposure resets your internal clock independently of immune responses
2 days ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
1 week ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
2 weeks ago7 studies
issue #32
Bright light preference disrupts mouse sleep patterns even without human lifestyle factors
3 weeks ago7 studies
issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
4 weeks ago7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
5 weeks ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
6 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
7 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
8 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief