Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior

Mar 28, 2017Current biology : CB

Support cells control daily rhythms in the brain’s internal clock and behavior

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Abstract

Ablation of the clock gene Bmal1 in SCN astrocytes lengthened the circadian period of clock gene expression and locomotor behavior.

  • Daily rhythms in astrocytes within the suprachiasmatic nucleus (SCN) influence wheel-running activity.
  • Lengthened circadian periods were observed following the removal of the clock gene Bmal1 from SCN astrocytes.
  • Excision of the CK1ε tau mutation from SCN astrocytes also resulted in extended rhythms in both the SCN and behavior.
  • These findings suggest that astrocytes in the SCN play a role in regulating circadian rhythms in neurons and overall behavior.

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