Nature structural & molecular biology

DAG transport by ATG2A brings in DGAT2 to help lipid droplets grow

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Updated

Abstract

Essence

ATG2A may help grow by moving to droplets and thereby recruiting DGAT2 for synthesis at the droplet surface.

Evidence

This mechanistic lipid-biology study combined ATG2A-deficiency, DGAT2-relocation, DGAT2-inhibition, and in vitro DAG-recruitment experiments to test lipid droplet expansion.

Caveat

The findings define a cellular mechanism for lipid droplet growth but do not establish tissue-level or disease-level consequences.

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Funding

Competing interests

1 of 9
authors report competing interests
8 report none
PubMed
Co-founded and advises Oria Bioscience.

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