Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan.
Adding Energy Import to Yeast Reveals a New Way to Extend Cell Lifespan
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Abstract
Depletion of ATP significantly reduces lifespan in budding yeast cells.
- Supplementation of ATP in the growth medium fully restores and extends lifespan.
- Elevated ATP levels inhibit catabolic processes, suggesting a suppression of glucose metabolism.
- The study establishes a direct link between cellular ATP levels and lifespan regulation.
- This work highlights energy metabolism as a potential target for interventions aimed at longevity.
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