Beta-d-glucan-based drug delivery system and its potential application in targeting tumor associated macrophages

Dec 6, 2020Carbohydrate polymers

Drug delivery using beta-d-glucan to target tumor-supporting immune cells

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Abstract

β-d-glucans are naturally occurring polysaccharides that may serve as effective carriers for targeting drug delivery in cancer immunotherapy.

These polysaccharides have immunomodulatory activities that could enhance therapeutic effects.
β-d-glucans are specifically recognized by immune cells, particularly macrophages, facilitating targeted delivery.
Targeting tumor-associated macrophages (TAMs) may improve cancer treatment by modulating immunity within the tumor microenvironment.
This strategy potentially reduces the need for high drug concentrations to directly kill cancer cells.
The review discusses various construction strategies and characteristics of different types of β-d-glucans for drug delivery applications.

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Use of polysaccharides as carriers in drug delivery system is a hot topic, especially those with specific recognition of immune cells, enabling them to be applied in targeting delivery system. β-d-glucans are naturally occurring non-digestible polysaccharides with immunomodulatory activities that have attracted increasing attention to serve as therapeutic agents or immune-adjuvants. Being able to be specifically recognized by immune cells like macrophages, β-d-glucans can be developed as promising carriers for targeting delivery with stability, biocompatibility and specificity when applied in immunotherapy. Targeting tumor associated macrophages (TAMs) is an emerging strategy for cancer immunotherapy since it exerts anti-cancer effects based on modulating body immunity in tumor microenvironment (TME). This new strategy does not require high concentration of drugs to kill cancer cells directly and lessen tumor recurrence by creating unique immune memory for malignant cells. In this review, construction strategies of polysaccharide-based drug delivery system of three types of β-d-glucan including non-yeast and yeast β-d-glucans as well as hyper-branched β-d-glucan are discussed with reference to their branching characteristics and conformation. The applications of these β-d-glucans as nano-carrier for drug delivery targeting TAMs are also discussed.

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Beta-d-glucan-based drug delivery system and its potential application in targeting tumor associated macrophages

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