Daily stress hormones may encourage glioblastoma growth and align tumor rhythms with the body’s daily cycle

Daily glucocorticoids promote or suppress glioblastoma growth depending on the time of day.

• Circadian rhythms may regulate tumor growth in glioblastoma through host signaling.
• Blocking signals related to the body's internal clock can significantly slow glioblastoma progression.
• High expression of glucocorticoid receptors in human glioblastoma is associated with increased mortality risk.
• Both mouse and human glioblastoma models exhibit circadian rhythms in key clock genes.
• Glucocorticoid signaling is involved in how glioblastoma aligns with the body's circadian system.

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