Daily stress hormones may support glioblastoma growth and align its daily rhythms with the body

Administering Temozolomide in the morning is associated with a 6-month increase in overall survival for glioblastoma patients.

• Daily Dexamethasone can either promote or suppress glioblastoma growth depending on the time of administration and specific clock genes.
• Blocking circadian signals, such as vasoactive intestinal peptide (VIP) or glucocorticoids, significantly slows glioblastoma growth and disease progression.
• Both mouse and human glioblastoma models exhibit intrinsic circadian rhythms in clock gene expression that align with host signaling via glucocorticoids.
• Glioblastoma appears to synchronize with the circadian cycle of the brain, which influences its growth through clock-controlled mechanisms.

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