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Abstract
Administering Temozolomide in the morning is associated with a 6-month increase in overall survival for glioblastoma patients.
- Daily Dexamethasone can either promote or suppress glioblastoma growth depending on the time of administration and specific clock genes.
- Blocking circadian signals, such as vasoactive intestinal peptide (VIP) or glucocorticoids, significantly slows glioblastoma growth and disease progression.
- Both mouse and human glioblastoma models exhibit intrinsic circadian rhythms in clock gene expression that align with host signaling via glucocorticoids.
- Glioblastoma appears to synchronize with the circadian cycle of the brain, which influences its growth through clock-controlled mechanisms.
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