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Changing brain networks of the circadian clock and how they may worsen in disease
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Abstract
Plasticity in phase synchrony among suprachiasmatic nuclei neurons may determine the amplitude of circadian rhythms.
- Phase synchrony among SCN neurons is associated with the response to continuous light.
- Synchronization may influence the capacity to adapt to seasonal changes in the environment.
- A decrease in circadian amplitude and phase-resetting capacity is linked to aging and disease processes.
- It remains unclear whether reduced amplitude results from loss of synchronization or loss of individual cell rhythms.
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