Progress in brain research

Changing brain networks of the circadian clock and how they may worsen in disease

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Plasticity in phase synchrony among suprachiasmatic nuclei neurons may determine the amplitude of circadian rhythms.

  • Phase synchrony among SCN neurons is associated with the response to continuous light.
  • Synchronization may influence the capacity to adapt to seasonal changes in the environment.
  • A decrease in circadian amplitude and phase-resetting capacity is linked to aging and disease processes.
  • It remains unclear whether reduced amplitude results from loss of synchronization or loss of individual cell rhythms.

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