Dynamic neuronal network organization of the circadian clock and possible deterioration in disease

Aug 11, 2012Progress in brain research

Changing brain networks of the circadian clock and how they may worsen in disease

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Abstract

Plasticity in phase synchrony among suprachiasmatic nuclei neurons may determine the amplitude of circadian rhythms.

  • Phase synchrony among SCN neurons is associated with the response to continuous light.
  • Synchronization may influence the capacity to adapt to seasonal changes in the environment.
  • A decrease in circadian amplitude and phase-resetting capacity is linked to aging and disease processes.
  • It remains unclear whether reduced amplitude results from loss of synchronization or loss of individual cell rhythms.

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