The endogenous circadian clock programs animals to eat at certain times of the 24-hour day: What if we ignore the clock?

Apr 21, 2018Physiology & behavior

The Body's Internal Clock Sets Meal Times: What Happens When We Ignore It?

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Abstract

Disruptions of the circadian clock are linked to metabolic dysfunctions associated with obesity and diabetes.

The circadian clock operates in nearly every cell to help the body adapt to daily environmental changes.
Research indicates that both environmental and genetic disruptions of this clock can lead to metabolic issues.
Metabolic dysfunctions related to circadian clock disruptions may include obesity and diabetes.
Ongoing studies suggest that understanding these interactions could influence the future of precision medicine.

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The discovery of the molecular mechanisms underlying the circadian clock, which functions in virtually every cell throughout the body to coordinate biological processes to anticipate and better adapt to daily rhythmic changes in the environment, is one of the major biomedical breakthroughs in the 20th century. Twenty years after this breakthrough, the biomedical community is now at a new frontier to incorporate the circadian clock mechanisms into many areas of biomedical research, as studies continue to reveal an important role of the circadian clock in a wide range of biological functions and diseases. A forefront of this exciting area is the research of interactions between the clock and energy metabolism. In this review, we summarize animal and human studies linking disruptions of the circadian clock, either environmental or genetic, to metabolic dysfunctions associated with obesity, diabetes, and other metabolic disorders. We also discuss how these advances in circadian biology may pave the way to revolutionize clinical practice in the era of precision medicine.

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The endogenous circadian clock programs animals to eat at certain times of the 24-hour day: What if we ignore the clock?

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Recent issues from the circadian biology brief