Estrogens and the circadian system

Circadian rhythms are ~24 h cycles influenced by molecular clocks in nearly every tissue.

• The suprachiasmatic nucleus (SCN) serves as the main circadian clock in mammals, coordinating tissue clocks with light-dark cycles.
• Estrogens interact with the circadian system to influence gene expression and cell biology.
• Circadian behavior varies across the estrous cycle, influenced by estrogen levels.
• Ovulation timing requires both estrogen and SCN signals to be aligned.
• Estrogen regulation of peripheral tissue clocks and metabolic rhythms has been demonstrated using circadian gene reporter mice.

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