Current topics in medicinal chemistrySep 25, 2025

Fluorine-Containing FDA-Approved Drugs in 2024: Their Importance, How They Are Made, and Medical Uses

Alzheimers & Treatments Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 27, 2026

Abstract

An extensive analysis of FDA-approved fluorine-containing drugs from 2015 to 2024 highlights their structural and functional benefits.

Fluorine enhances pharmacological properties such as bioavailability, metabolic stability, and target affinity.
Fluorinated drugs have become essential in drug design, influencing research in both academic and industrial sectors.
The review discusses the mechanisms of action of the latest fluorine-approved drugs from 2024.
Detailed synthetic methodologies for these drugs are also presented.

Simplified

For the past 75 years, the development pipeline of fluorinated drugs has exemplified the strategic use of fluorine to enhance key pharmacological properties, including bioavailability, metabolic stability, and target affinity. Consequently, fluorine incorporation has become a cornerstone in drug design, inspiring continuous research and development efforts across both academic and industrial sectors. Each year, numerous reviews highlight the ongoing importance of fluorinated drugs and aim to keep the field updated on emerging advancements. This review provides a comprehensive evaluation of the structural and functional benefits of fluorine in medicinal chemistry, presenting an extensive analysis of FDA-approved fluorine-containing drugs from 2015 to 2024. Special attention is paid to the latest approvals from 2024, with a focus on their mechanisms of action and detailed synthetic methodologies.

Fluorine-Containing FDA-Approved Drugs in 2024: Their Importance, How They Are Made, and Medical Uses

Abstract

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