Chemical interactions between gut bacteria and gene regulation linked to the body’s internal clock

Circadian rhythms are influenced by the gut microbiota through modulation of host epigenetic pathways.

• The gut microbiota impacts host physiology via metabolites and structural components.
• Microbial regulation of host circadian rhythms is associated with epigenetic modifications, particularly histone changes.
• Current studies indicate the microbiota's role in synchronizing host biological functions with the day/night cycle.
• Understanding these interactions may advance knowledge of circadian disorders.
• Challenges remain in studying the microbiota's influence on circadian rhythms and the underlying mechanisms.

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