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Association of healthy lifestyle, metabolic alterations and lower mortality risk of IBD patients: a prospective cohort and mediation analysis
Healthy lifestyle, metabolism changes, and lower death risk in people with inflammatory bowel disease
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Abstract
During a median follow-up of 14.6 years, 583 deaths were identified among 5052 patients with inflammatory bowel disease (IBD).
- Patients with a favourable lifestyle had a significantly lower risk of all-cause mortality in IBD, with a hazard ratio of 0.56.
- Favourable lifestyle also correlated with reduced mortality risk in ulcerative colitis (hazard ratio of 0.61) and Crohn's disease (hazard ratio of 0.49).
- Approximately 18.9% of the reduced risk of mortality was potentially mediated by metabolic signatures linked to lifestyle.
- Higher values were associated with lower all-cause mortality, with a hazard ratio of 0.65 for values above the median.
- Similar associations were observed in subgroup and sensitivity analyses.
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Key numbers
0.56
Lower mortality risk
Hazard Ratio comparing favourable vs. unfavourable lifestyle
18.9%
Mediated risk reduction
Percentage of mortality risk reduction mediated by metabolic changes
583
Total deaths observed
Total deaths among 5052 IBD patients over 14.6 years